解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The stability of internally cross-linked casein micelles against disruption by urea (which disrupts hydrogen bonds and hydrophobic interactions) and trisodium citrate (which sequesters micellar calcium phosphate) was investigated. Addition of urea (0-6 mol L-1) and/or citrate (0-50 mmol L-1) progressively reduced the ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm061070m
更新日期:2007-04-01 00:00:00
abstract::The dynamics of bacterial colonies is complex in nature because it correlates the behavior of numerous individual cells in space and time and is characterized by emergent properties such as virulence or antibiotics resistance. Because there is no clear-cut evidence that periodic swarming of P. mirabilis colonies is ru...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm061181l
更新日期:2007-04-01 00:00:00
abstract::A lamellar compound resulted from reaction of acrylic acid inside crystalline beta-chitin and the structure was investigated. Beta-chitin acts like a layered crystal, having stacked molecular sheets composed of parallel chains bound in one direction by intermolecular amide hydrogen bonding. Small guest molecules can b...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060643s
更新日期:2007-04-01 00:00:00
abstract::Injectable in situ crosslinkable biomaterials seeded with multipotent progenitor cells and coupled with minimally invasive arthroscopic techniques are an attractive alternative for treating irregularly shaped osteochondral defects. An in situ crosslinkable poly(lactide-co-ethylene oxide-co-fumarate) (PLEOF) macromer h...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060671a
更新日期:2007-03-01 00:00:00
abstract::Polymers are appealing as pH-responsive elements of multicomponent systems designed to promote cytosolic delivery of macromolecular drugs (including proteins and genes), but so far the delivery efficiency achieved has been relatively modest. Therefore, the aim of this study was to apply several physicochemical techniq...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060930w
更新日期:2007-03-01 00:00:00
abstract::Nanofibrous biocomposite scaffolds of type I collagen and nanohydroxyapatite (nanoHA) of varying compositions (wt %) were prepared by electrostatic cospinning. The scaffolds were characterized for structure and morphology by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), atomic fo...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060879w
更新日期:2007-02-01 00:00:00
abstract::There has been little study on the effect of composition or molecular weight on the biodegradation rate of photo-cross-linked biodegradable aliphatic polyesters though such information is important for tissue engineering scaffolds. We have synthesized a new series of photopolymerizable linear poly(epsilon-caprolactone...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060766c
更新日期:2007-02-01 00:00:00
abstract::The structure of the Ca--alginate junction zones was investigated with X-ray scattering on gels prepared with different methods. Fiber diffraction reveals the popular egg-box model may not be the only possible structure for the junction zones. The (001) reflection, which should be extinguished due to 2/1 helical confo...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060550a
更新日期:2007-02-01 00:00:00
abstract::Images of high methoxyl orange pectin deposited from solution and high methoxyl sugar acid gels (HMSAG) were obtained by atomic force microscopy (AFM) in the tapping mode. For the first time, images of pectin deposited from water revealed that the transition from pectin networks to individual molecules or aggregates t...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0607729
更新日期:2007-02-01 00:00:00
abstract::The supramolecular organization of self-assembled stoichiometric complexes formed by dodecyltrimethylammonium cations and ionized poly(gamma-glutamic) acid has been investigated in chloroform solution. Atomistic molecular dynamics simulations have been performed considering three different starting conformations for t...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060927c
更新日期:2007-02-01 00:00:00
abstract::Here we present time-resolved in situ transmission electron microscopy (TEM) observations and real-time manipulation of nematic ordered cellulose and ultradrawn polyethylene films. Drawn films of these two polymers exhibited a unique response to the low-dose electron beam. Electron beam damage was minimal based on ret...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060546z
更新日期:2007-01-01 00:00:00
abstract::Nanoparticles (NPs) composed of chitosan (CS) and poly(gamma-glutamic acid) (gamma-PGA) were prepared by a simple ionic-gelation method for oral insulin delivery. Fourier transform infrared (FT-IR) spectra indicated that CS and gamma-PGA were ionized at pH 2.5-6.6, while X-ray diffractograms demonstrated that the crys...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0607776
更新日期:2007-01-01 00:00:00
abstract::Nearly monodispersed silica nanoparticles having a controlled size from 5 to 450 nm were synthesized via a sol-gel process, and then the optimum conditions for the surface treatment of the synthesized silica nanoparticles with a silane coupling agent (i.e., 3-methacryloxypropyltrimethoxysilane (gamma-MPS)) were explor...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060560b
更新日期:2007-01-01 00:00:00
abstract::The effect of moisture content and temperature on water diffusion into a modified high amylose (< or = 90%) maize thermoplastic starch blend was investigated. Gravimetric and magnetic resonance imaging (MRI) studies were conducted to elucidate the diffusion mechanism and diffusion coefficients for this system. The dif...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060791i
更新日期:2007-01-01 00:00:00
abstract::This paper presents the formation of a novel biomimetic interface consisting of an electrolessly deposited gold film overlaid with a tethered bilayer lipid membrane (tBLM). Self-assembly of colloidal gold particles was used to create an electrolessly deposited gold film on a glass slide. The properties of the film wer...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0603995
更新日期:2006-12-01 00:00:00
abstract::Two poly(amido-amine)s (oligoPAM and oligoNER) containing bis-phosphonate residues were obtained by a Michael-type polyaddition of pamidronate and neridronate to 1,4-bis(acryloyl)piperazine. The SEC (size-exclusion chromatography) and the MALDI-TOF (matrix assisted laser desorption ionization) analyses were consistent...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0607630
更新日期:2006-12-01 00:00:00
abstract::A wool fiber sample was submitted to chemical-free steam explosion in view of potential exploitation of keratin-based industrial and farm wastes. Fiber keratin was converted into a dark-yellow sludge that was submitted to phase separation by filtration, centrifugation, and precipitation of the soluble materials from t...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060597w
更新日期:2006-12-01 00:00:00
abstract::Experimental and theoretical investigations of the swelling and mechanical properties of hydrogels formed from chitosan, bovine serum albumin (BSA), and chitosan/BSA mixtures cross-linked with genipin were performed. The properties of cross-linked chitosan hydrogels were explained in terms of its polyelectrolyte behav...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060133y
更新日期:2006-11-01 00:00:00
abstract::As a programmable biopolymer, DNA has shown great potential in the fabrication and construction of nanometer-scale assemblies and devices. In this report, we described a strategy for efficient manipulation of gold nanoparticle-bound DNA using restriction endonuclease. The digestion efficiency of this restriction enzym...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060517o
更新日期:2006-11-01 00:00:00
abstract::Spider silk has been extensively studied for its outstanding mechanical properties. Partial intermediate and C-terminal sequences of different spider silk proteins have been determined, and during the past decade also N-terminal domains have been characterized. However, only some of these N-terminal domains have been ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060693x
更新日期:2006-11-01 00:00:00
abstract::Single-molecule measurements of the interaction of leukocyte function-associated antigen-1 (LFA-1), expressed on Jurkat T cells, with intercellular adhesion molecules-1 and -2 (ICAM-1 and ICAM-2) were conducted using atomic force microscopy (AFM). The force spectra (i.e., unbinding force versus loading rate) of both t...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060559c
更新日期:2006-11-01 00:00:00
abstract::Cell cultivation on the surface of a novel poly(N-isopropylacrylamide) (PNIPA) hydrogel (N-NC gel), consisting of a specific type of organic (PNIPA)/inorganic (clay) network, was studied using three cell types; HepG2 human hepatoma cells, human dermal fibroblasts, and human umbilical vein endothelial cells. For the fi...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060549b
更新日期:2006-11-01 00:00:00
abstract::There is a distinct need for antimicrobial compounds that can act at surfaces without leaching into the environment. Such materials should be easy to synthesize, be easy to apply to surfaces, and display reasonable levels of antimicrobial and antifungal activity. Here we describe such a surface-active compound and dem...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060476w
更新日期:2006-10-01 00:00:00
abstract::A multifunctional macromolecular thiol (TPVA) obtained by esterification of poly(vinyl alcohol) (PVA) with 3-mercaptopropionic acid was characterized by a combination of NMR, IR, transmission electron microscopy (TEM), and differential scanning calorimetry (DSC), and was used as a wheat gluten (WG) reactive modifier. ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060432n
更新日期:2006-10-01 00:00:00
abstract::We describe investigations of insulin release from thermoresponsive microgels using variable temperature (1)H NMR. Microgel particles composed of poly(N-isopropylacrylamide) were loaded with the peptide via a swelling technique, and this method was compared to simple equilibrium partitioning. Variable temperature (1)H...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060718s
更新日期:2006-10-01 00:00:00
abstract::The synthesis, characterization, and degradation kinetics of three alpha-cyclodextrin (alpha-CD)-poly(ethylene glycol) (PEG) polyrotaxanes with endcaps that were installed using Cu(I)-catalyzed Huisgen cyclization is reported. PEG1500, azidated with azidoacetic acid, was threaded with alpha-CD to form a pseudopolyrota...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0602076
更新日期:2006-09-01 00:00:00
abstract::Molecular orientation distributions in the crystalline and amorphous regions of a biaxially oriented poly(L-lactic acid) film were analyzed fully by polarized Raman spectroscopy. Raman bands at 926 and 875 cm(-1) were chosen for the determination of the most probable molecular orientation distribution functions for th...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060326l
更新日期:2006-09-01 00:00:00
abstract::In this work, we have analyzed the structural, topographical, and surface dilatational characteristics of pure beta-lactoglobulin adsorbed films and the effect of the self-assembly of monoglycerides (monopalmitin or monoolein) in beta-lactoglobulin films at the air-water interface. Measurements were performed in a sin...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060144r
更新日期:2006-09-01 00:00:00
abstract::Enzymatic ring-opening copolymerization of 5-benzyloxy-trimethylene carbonate (BTMC) and 1,4-dioxan-2-one (DON) was investigated for the first time. Immobilized porcine pancreas lipase (IPPL) on silica particles was selected to perform the copolymerization. A series of novel biodegradable copolymers with different com...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060070j
更新日期:2006-08-01 00:00:00
abstract::alpha-Conotoxins possess a conserved four-cysteine framework and disulfide linkages (C(1)(-)(3), C(2)(-)(4)) that fold toward the globular conformation with absolute fidelity. Despite the presence of a similar conserved set of cysteine framework, chi/lambda-conotoxins adopt an alternate disulfide-pairing (C(1)(-)(4), ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060269w
更新日期:2006-08-01 00:00:00
abstract::Spider dragline silk with its superlative tensile properties provides an ideal system to study the relationship between morphology and mechanical properties of a structural protein. Accordingly, we synthesized two hybrid multiblock copolymers by condensing poly(alanine) [(Ala)(5)] blocks of the structural proteins (sp...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060199t
更新日期:2006-08-01 00:00:00
abstract::A series of alginates isolated from the stem and leaf of a brown algae (Laminaria hyperborea), bacterial mannuronan, in vitro epimerized mannuronans, and periodate oxidized alginates were analyzed by size-exclusion chromatography (SEC) combined with online multiangle laser light scattering (MALS) and viscometry (colle...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060099n
更新日期:2006-07-01 00:00:00
abstract::The clinical application of holmium-loaded poly(L-lactic acid) (PLLA) microspheres for the radionuclide treatment of liver malignancies requires in depth understanding of the degradation characteristics of the microspheres. To this end, an in-vitro degradation study was conducted. PLLA-microspheres with and without Ho...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060230r
更新日期:2006-07-01 00:00:00
abstract::The recombinant amylosucrase from Neisseria polysaccharea was used to glucosylate glycogen particles in vitro in the presence of sucrose as the glucosyl donor. The morphology and structure of the resulting insoluble products were shown to strongly depend on the initial sucrose/glycogen weight ratio. For the lower rati...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050988v
更新日期:2006-06-01 00:00:00
abstract::Strategies to prevent the uptake of modified low density lipoproteins (LDLs) by immune cells, a major trigger of inflammation and atherogenesis, are challenged by complex interfacial factors governing LDL receptor-mediated uptake. We examine a new approach based on a family of "nanoblockers", which are designed to exa...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0600872
更新日期:2006-06-01 00:00:00
abstract::Hyperbranched poly(amino ester)s containing tertiary amines in the core and primary, secondary, and tertiary amines in the periphery, respectively, were evaluated for DNA delivery in vitro. The same core structure facilitated the investigation on the effects of the terminal amine type on the properties of hyperbranche...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0601878
更新日期:2006-06-01 00:00:00
abstract::A novel cellulose derivative, 6-O-dihydrophytylcellulose (DHPC), was first synthesized via a ring-opening polymerization and allowed to self-assemble onto an air-water interface. Langmuir-Blodgett (LB) films were characterized with atomic force microscope (AFM), UV-vis spectroscopy, and Fourier transform infrared spec...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060083x
更新日期:2006-06-01 00:00:00
abstract::The intermolecular distributions of amide groups within two commercial LMA pectins was studied after removal of the methyl esters followed by fractionation of the different populations by anion exchange chromatography. The populations obtained had almost equal degrees of amidation while the values of the degree of blo...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050960j
更新日期:2006-06-01 00:00:00
abstract::Six methyl celluloses (MCs), one with a degree of substitution (DS) of 1.32 and five with DS between 1.83 and 1.88, were thoroughly investigated. Monomer composition and methyl distribution in the polymer chain were analyzed after total or partial random hydrolysis and appropriate derivatization with gas chromatograph...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050941+
更新日期:2006-05-01 00:00:00
abstract::The new combinations of monomers presented in this work were evaluated in order to create an elastic material for potential application in soft tissue engineering. Thermoplastic elastomers (TPE) of trimethylene carbonate (TMC) with L-lactide (LLA) and 1,5-dioxepan-2-one (DXO) have been synthesized using a cyclic five-...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060081c
更新日期:2006-05-01 00:00:00